Breast cancer is the most common cancer in women. The literature shows that physical activity in conjunc-tion with healthy eating habits, that is, a diet low in lipids and sugars, contributes to decrease the process of carcinogenesis, since both decrease the cytokines signaling the inflammatory cascade, such as TNF-alpha, TGF -beta and Interleukins among others. In addition, obesity and physical inactivity are correlated with a state of hyperlipidemia in plasma serum, which also favor the recruitment of inflammatory cytokines and macrophages, due to cholesterol catabolism. Based on that, we didan integrative bibliographic review ofthe influence of physical activity on the prognosis of patients with breast cancer, since it is a neoplasm of great incidence worldwide. Scientific articles were consulted in the PubMed database (National Library of Medicine and The National Institute of Health) with the descriptors "breast cancer", "physical activity" and "prognostic". After a careful reading in the research source 25 articles were found with the keywords, of which 16 were selected applying inclusion and exclusion criteria. The data suggest that physical exercise contributes to a decrease in the immune response, as well as, contributes to the development of a tumormicroenvironment unfavorable to the nutrition of breast tumor cells. In summary, physical activity and heal-thy lifestyle habits substantially corroborate for decreased carcinogenesis and improve the prognosis of women with of breast cancer.