Human Papilloma Virus (HPV) infection is one of the most frequent sexually transmitted diseases (STDs) in the world and affects most sexually active young people at some point in their lives. In this context, given the various factors that can influence knowledge and adherence to the HPV vaccine, this study a im stok-nowande valuate the understanding of adolescents about this vaccine through ananaly ticalcross-sectional study in the city of Fortaleza with public school students, EEF Escola Municipal Colônia Z8,private schools Escola Pequeno Mestre and Colégio Canon and users of Basic Health Units: Aida Santos, Benedito Arthur de Carvalho and Célio Brasil Girão. The study was conducted with 231 students and 105 patients, through questionnaires with questions about: personal data, socioeconomic level, education, knowledge about HPV, vaccination and public health. Fortunately, the majority of participants, 83.34%, said they knew HPV and the quadrivalent HPV vaccine. The factors associated with the knowledge report about HPV vaccination are: being female, 76.92%, parent having average education level, 47%, or higher, 33%, having family income greater than 02 minimum wages, 69%, using the private education service 95.45%. It follows that there is a deficit in adherence and knowledge about HPV and little qualification of what is known, favoring actions with potential risk to health, including the partner. Thus, as indicated the need to reformulate the vaccine presentation strategy to reach the threat of the target audience.