Situs inversus totalis is an uncommon congenital condition characterized by the mirror-image arrangement of thoracic and abdominal organs. Although many individuals remain asymptomatic throughout life, the condition may complicate the recognition of acute abdominal diseases, especially in surgical settings. This review gathers studies regarding laparoscopic cholecystectomy in patients with situs inversus, emphasizing the diagnostic and technical challenges involved in clinical management. Articles discussing anatomical aspects, imaging methods, preoperative planning, and ergonomic adaptations required during surgical procedures were analyzed. Current literature demonstrates that laparoscopic cholecystectomy can be safely performed in these patients when adequate anatomical recognition and experienced surgical teams are available. Individualized planning and accurate interpretation of imaging examinations directly contribute to reduced complications and improved postoperative outcomes.